Acute Phase Proteins (APPs)
Acute Phase Proteins (APPs) are produced by all mammalian species in response to physical trauma such as tissue damage, infection or inflammatory conditions.
ACUTE PHASE PROTEINS (APPs)
Their main function in all animals is to assist in the fight against infection, minimise tissue damage and to speed up the healing process. They all share the following characteristics:
• APPs are plasma proteins that rapidly increase (or decrease) in concentration in response to inflammation, infection or trauma.
• APPs provide an objective measure of the health status of an animal because their concentration is related to the severity of the underlying clinical condition.
• Due to the speed of the APP response, measuring APP concentrations can help identify sub-clinical (before symptoms) conditions.
Serum CRP levels increase dramatically within 4 – 6 hours of an inflammatory stimulus. If the inflammation ceases, CRP concentrations in the blood peak within 48 hours and then return to normal level within 1 – 2 weeks.
This acute response to a broad spectrum of inflammatory stimuli (bacterial infection and tissue damage resulting from disease or injury) provides a rapid and reliable measure of disease progression and recovery.
Our application notes on the uses of CRP in veterinary medicine and using CRP to monitor resolution and recurrence in canine steroid responsive meningitis-arteritis (SRMA) can be seen below and provides insights into the significant value this can provide to canine health.
To find out more about the applications of acute phase proteins in veterinary medicine, please contact our Technical Support team.
ACUTE PHASE PROTEIN KITS
ACUTE PHASE PROTEIN KITS
We also offer APP kits for veterinary laboratories. Our Canine CRP kit is available in two formats:
- Turbidimetric immunoassay that is compatible with automated clinical bioanalysers for high sample throughput
- 96-well ELISA plate format for smaller laboratories
Both assays have very good correlation to each other and can be used interchangeably as required.
You can find information on our kits offerings in our Immunoassay kit section HERE
For further assistance regarding the kits or reference laboratory tests, please contact our customer services department on 0800 3 047 047 or +44(0)1904 217071
USES OF CRP IN VETERINARY DIAGNOSTICS
Despite CRP playing a similar role in the dog, to date it has not been used widely in veterinary medicine. APPs are highly sensitive indicators of inflammation but they do lack specificity. It is likely that the lack of specificity plus the fact that APP testing has been suggested for a bewildering range of applications has resulted in the tests being underutilised in the veterinary clinic. However, APP testing can be very useful when employed in the right situations.
This application note has therefore been prepared to summarise the key areas where the CRP test can offer significant clinical value in canine health.
You can download the application note HERE.
CRP IN MONITORING CANINE SRMA
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